SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NIFUROXAZIDE AND ASCORBIC ACID EUTECTIC MIXTURE

Résumé

This study investigated the formation of a eutectic mixture comprising an active pharmaceutical ingredient (API), an oral antibiotic, and ascorbic acid as a coformer. The aim was to evaluate the nature of the resulting mixture and to explore strategies for enhancing its dissolution rate, ultimately improving bioavailability. The eutectic mixture was synthesized using the neat grinding method in an agate mortar, chosen for its ability to facilitate molecular interactions without the need for solvents. Characterization of the mixture was performed using powder X-ray diffraction (PXRD) to analyze crystallographic changes, infrared spectroscopy (IR) to detect functional group interactions, and nuclear magnetic resonance (NMR) to assess molecular-level interactions. Additionally, differential scanning calorimetry (DSC) was employed for thermal analysis to confirm the thermal behavior and stability of the mixture. To study its biological activity a test was made against Escherichia Coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans.